Department of Chemical Engineering, Tsinghua University
Zhou Lan
2017-2022: Department ofChemical Engineering, Tsinghua University (Doctor-in progress) 2013-2017: Department ofChemical and Biochemical Engineering, Xiamen University (Bachelor) Email: 443653454@qq.com Project: Miniaturization of key synthesis reactions ofdye intermediates in the microreactor
Organic intermediates are the cornerstone of the development of the fine chemical industry, but the conventional synthesis process of organic intermediates has problems such as poor safety, low efficiency, and uncontrollable processes due to the limitations of batch operation in kettles. In particular, the key synthesis reactions of dye intermediates such as amination, nitration, and chlorination are in urgent need of developing new processes that are efficient, safe, controllable, and integrated. To this end, based on the outstanding advantages of microfluidic technology in terms of mass transfer, heat transfer, safety, and controllability, etc., our works proposed the miniaturization of key synthesis reactions of dye intermediates in the microreactor. The purpose of our works are to: develop new miniaturized synthesis techniques for key synthesis reactions of dye intermediates; to explore the feasibility of strategies such as microdispersion state matching, reaction phase control; to study the reaction kinetics and mechanisms involved in key synthesis reactions of dye intermediates; establish reaction kinetics model, build reaction network; provide certain theoretical guidance for process optimization, and develop and integrate a series of continuous and efficient synthesis processes for disperse dye intermediates. Publication
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